By P. Jolles, H. Zahn
For people, hair has consistently been an indication of energy and gear. in addition to verbal exchange and adornment, certainly one of its major services is to guard the organism opposed to environmental impacts. This quantity offers perception into the molecular and mobile foundation of the advanced mode of hair formation and degeneration, its development and protecting function. cognizance is focussed at the cytoskeleton, the keratinization technique, cell-cell adhesion and verbal exchange, pigmentation, morphology and histochemistry, all of that are important for the steadiness or the beauty therapy of human hair. in addition, the molecular foundation of ailments is defined, to help in remedy and probably genetic counselling companies.
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Additional info for Formation and Structure of Human Hair
This finding confirms reports that abnormal keratin proteins are found in this disease. Both EBS and EHK seems to be diseases linked to dominant mutations in keratin genes (McLean et at, 1994a). The breakdown of appropriate three dimensional tissue architecture caused by the collapse of the intracellular skeleton is found in both diseases. Therefore, one of the important roles of Human epidennal keratinocyte: Keratinization processes 23 keratins in the epidermis is establishment and maintenance of the appropriate three-dimensional epithelial structure.
Current knowledge of interactions between epithelium and mesenchyme provides evidence for a sophisticated bidirectional growth regulation. g. interleukin-6, epidermal growth factor, substance P etc. , 1993; Paus, 1996; Paus and Czametzki, 1992; Philpott and Kealey, 1994; Reynolds and lahoda, 1992) but their number is still growing. The human terminal or guard hair follicle cycles through a growing or anagen phase followed by regressive catagen and resting telogen (Chase, 1954). Cotsarelis et ai.
Pediatr. 88: 456-458. M. (1988) Retinoic acid and thyroid honnone induce gene expression through a common responsive element. Nature 336:262-265. , Eichner, R. T. (1984) Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J. Cell Bioi. 98: 1397 -1406. Formation and Structure of Human Hair ed. by P. Jolles, H. Zahn and H. Hocker © 1997 Birkhauser Verlag Basel/Switzerland Histochemistry of the human hair follicle U.
Formation and Structure of Human Hair by P. Jolles, H. Zahn