By Christina Bolander-Gouaille
During the final 10-12 years, the examine on homocysteine has develop into very lively. approximately 1500 of articles are actually released every year on homocysteine and the supplementations concerned with its metabolism. A disturbed homocysteine metabolism may be an underlying issue for being pregnant issues and fetal malformations, heart problems, dementia, psychiatric and neurologic issues and probably carcinogenesis. A disturbed homocysteine metabolism can ordinarily be normalised by means of remedy with folate and/or vitamines B12 and B6. a lot of those findings hence at once predicament so much practitioners. despite the fact that, if there are solid stories protecting unmarried features of this examine, those are released in specialized journals. the writer has realised the problems for the practitioner in retaining up-to-date. This moment variation has been completely up to date and likewise deals extra info at the supplementations. Over 1600 references are made available.
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Additional info for Focus on Homocysteine and the Vitamins: Involved in its metabolism
Thrombin-antithrombin complexes (TAT) and tHcy were higher in patients than in controls, and a highly significant positive correlation between fasting tHcy and both TF and TAT was found, and also a significant correlation with TFPI (Marcucci et al. 2000). A study of 57 acute MI and 6o unstable angina pectoris patients showed an elevation of factor 1+2 and also of factor Vlla in the patients with unstable angina pectoris, as compared to controls. There was also a signifi- cant correlation between fasting tHcy and prothrombinfragment 1+2 and factor VIIa, which could explain he prothrombotic effects of Hcy in acute coronary syndromes (Al-Obaidi et al.
In a recent study of patients with peripheral vascular disease, copper positively correlated with tHcy in the patients, but not in the controls (Mansoor et al. 2000 ). Copper is shown to increase the release of Hcy, lower the reduced fractions of thiols, and enhance the effects of Hcy in experimental studies (e. g. Nishinaga et al. 1993, Bultberg et al. 1998b, 2000, Emsley et al. 1999, Xu et al. 2000 ). The presence of copper greatly enhanced the inhibitory effect of Hcy on NO-mediated relaxation in a study of isolated rat aortic rings.
Plasma tHcy was significantly correlated with liver and brain tissue SAH levels (Dayal et al. 200I). These findings support that elevated SAH may play a role in promoting atherosclerosis via inhibition of methylation reactions. 50 Focus on homocysteine and the vitamins © Chambers J. 2001. Personal communication. Presented at the 3rd International Conference on Homocysteine, July 2001. All rights reserved. Reprinted with permission. Recent studies also suggest that Homocysteine thiolactone may alter protein function, and underlie atherosclerosis.
Focus on Homocysteine and the Vitamins: Involved in its metabolism by Christina Bolander-Gouaille