By O. Schück (auth.)
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This method minimizes the influence of slow-reacting, non creatinine plasma chromogens and thus provides an estimate of true creatinine concentration. MEASUREMENT OF GFR BY MEANS OF RADIONUCLIDES In recent years measurement of GFR in clinical practice has been also carried out by following the kinetics of substances, labelled with radionuclides, which are excreted by glomerular filtration only. 36 These methods consist of a single intravenous application of the labelled substance and measurement of the decrease of activity in plasma.
Modification of diphenylamine method for determination of inulin. Proc. Soc. expo BioI. Med. 49: 111, 1942 40 Hayslett, J. , Epstein, F. : Functional correlates of compensatory renal hyper-trophy. J. clin. Invest. 47: 774, 1968 Healy, J. : Clinical assessment of glomerular filtration rate by different forms of creatinine clearance and a modified urinary phenolsulphonphthalein excretion test. Am. J. Med. 44: 348,. : Determination of serum creatinine by a direct colorimetric method. Clin. chim.
Fig. 15: Relationship between concentration index of inulin (U /P) in and the ratio of clearance of urea and inulin (Cu/Cin) under conditions of various diuretic states (Chassis and Smith 1938). 46 This last Fig. e. ratio less than 8). This finding indirectly suggests that the permeabilities of the proximal and distal tubules for urea are not equivalent. The proximal segment is more permeable to urea than the distal. Micropuncture data in recent years has complemented the above data based upon clearance experiments.
Examination of Kidney Function by O. Schück (auth.)