By Patricia Molina
The most sensible endocrine overview to be had for the USMLE Step 1
The fourth version of Endocrine Physiology offers accomplished assurance of the fundamental technological know-how and anatomy at the back of endocrine functionality. With its specialize in must-know ideas, Endocrine Physiolology is the simplest evaluate to be had for the USMLE Step 1 and definitely the right reference for citizens and fellows.
- NEW! boxed medical case situations permit scholars to use info to actual lifestyles situations
- Learning aids contain goals, key techniques, a precis, and evaluation questions
- Covers the rules of endocrinology and metabolism on a system-by-system, organ-by-organ basis
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Additional info for Endocrine Physiology
SUGGESTED READINGS Bourque CW, Oliet SHR. Osmoreceptors in the central nervous system. Annu Rev Physiol. 1997;59:601. [PMID: 9074779] de Bree FM. Trafficking of the vasopressin and oxytocin prohormone through the regulated secretory pathway. J Neuroendocrinol. 2000;12:589. Gimpl G, Fahrenholz F. The oxytocin receptor system: Structure, function, and regulation. Physiol Rev. 2001;81:629. [PMID: 11274341] Melmed S. Acromegaly. NEJM . 2006;355:2558–2573. [PMID: 17167139] Endocrine Physiology, 3e >Chapter 3.
The role of oxytocin in males is not clear, although recent studies have suggested that it may participate in ejaculation. OXYTOCIN RECEPTORS The physiologic effects of oxytocin are achieved by binding to cell membrane Gq/11 protein–coupled oxytocin receptors expressed in the uterus, mammary glands, and brain. Binding of oxytocin to the receptor activates phospholipase C, producing an increase in inositol trisphosphate and 1,2-diacylglycerol, which in turn results in an increase in cytosolic calcium concentrations.
FUNCTIONAL ANATOMY The hypothalamus is the part of the diencephalon located below the thalamus and between the lamina terminalis and the mamillary bodies forming the walls and the floor of the third ventricle. At the floor of the third ventricle, the 2 halves of the hypothalamus are rejoined to form a bridge-like region known as the median eminence (Figure 2–2). The median eminence is important because this is where axon terminals of hypothalamic neurons release neuropeptides involved in the control of anterior pituitary function.
Endocrine Physiology by Patricia Molina