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New PDF release: Drug Therapy for Type 2 Diabetes

By Andrew Krentz

ISBN-10: 1908517646

ISBN-13: 9781908517647

This Adis Pocket Reference provides an up to date, succinct, and functional method of drug remedy for kind 2 diabetes.

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Extra resources for Drug Therapy for Type 2 Diabetes

Example text

They bind to the enzymes with high affinity preventing the 47 Andrew J. Krentz cleavage of disaccharides and oligosaccharides to monosaccharides. In patients whose diet includes complex carbohydrates, a-glucosidase inhibitors can reduce postprandial glucose concentrations by retarding the absorption of monosaccharides. Each a-glucosidase inhibitor exhibits somewhat different affinities for the range of a-glucosidase enzymes. By transferring glucose absorption more distally a-glucosidase inhibitors may alter the release of glucose-dependent incretin hormones that enhance nutrientinduced insulin secretion.

Biguanides Metformin (dimethylbiguanide) is the only biguanide available in most countries. Phenformin was tarnished by lactic acidosis and was withdrawn from the UK in the late 1970s. Metformin was introduced in the USA in 1995. While metformin carries a much lower risk of lactic acidosis than phenformin, clinicians are required to ensure that appropriate steps are taken to minimise the occurrence of this potentially life-threatening sideeffect. Metformin is thought to be the most commonly prescribed oral glucose-lowering agent worldwide.

There is half a century of clinical experience with biguanides and sulphonylureas. Drugs within these archetypal classes illustrate the potential for clinically important differences between individual compounds. These differences are reflected principally in safety and tolerability rather than appreciable differences in long-term efficacy, although there is some support for the latter. The UK Prospective Diabetes Study (UKPDS) was completed just as a new class of oral glucose-lowering agents became available – the thiazolidinediones.

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Drug Therapy for Type 2 Diabetes by Andrew Krentz

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