By Wen Xie
Drug Metabolism in Diseases is a finished reference dedicated to the present nation of analysis at the effect of varied sickness states on drug metabolism. The booklet comprises precious insights into mechanistic results and examples of the way to appropriately expect drug metabolism in the course of those varied pathophysiological states.
Each bankruptcy sincerely provides the consequences of adjustments in drug metabolism and drug transporters on pharmacokinetics and disposition. this can be a certain and valuable process for all these eager about drug discovery and improvement, and for clinicians and researchers in drug metabolism, pharmacology, and medical pharmacology.
- Written and edited through leaders in drug metabolism from academia and industry
- Covers vital issues, similar to pharmacogenomics, drug metabolism in transplant sufferers, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more
- Highlights subject matters of significance in drug discovery and improvement, and for secure and potent drug use within the clinic
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Additional info for Drug Metabolism in Diseases
30 2. 3 Regulation of P450 expression in cultured human hepatocytes by cytokines and lipopolysaccharide (LPS). The data are taken from a previous publication (Aitken and Morgan, 2007). The percentage change from control hepatocytes is shown. Results are the mean of nine different hepatocyte preparations from different livers. 05, one-way ANOVA and Dunnett test. , 1993). Although current culture techniques help restore the adult hepatic phenotype, there are likely to be at least quantitative differences in responses compared with the liver.
Helicobacter pylori Helicobacter pylori infection of the gastric mucosa is causative of peptic ulcers and is associated with other gastrointestinal diseases. In cirrhotic patients, H. , 2001). In cirrhotic patients with HCV infection, H. , 2003). These studies showed that infection can downregulate P450 activity in humans even against a background of impaired liver function. , 1998). Parasitic Infections Malaria The impact of malaria on the pharmacokinetics of the antimalarial drug quinine is well documented.
32 2. 1 Evidence for Regulation of Human P450 Enzymes by Various Cytokines Humans/Model Cytokine System Effect References Patients with cancer Decreased CYP1A2, 2C, 2E1, 3A4 protein and activity Elkahwaji et al. (1999) Hepatocytes Decreased CYP3A4 mRNA, KC dependent Sunman et al. (2004) Hepatocytes Minimal effect on CYP3A4 with or without KC (no IL-2 receptor detected) Nguyen et al. (2015) IL-4 Hepatocytes, hepatoma cells Induced CYP2E1 mRNA Abdel-Razzak et al. (1993), Abdel-Razzak et al. (2004), and Wang et al.
Drug Metabolism in Diseases by Wen Xie