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Download e-book for kindle: Drug Discovery and Evaluation: Safety and Pharmacokinetic by Franz J. Hock (auth.), H. Gerhard Vogel Prof., Franz Jakob

By Franz J. Hock (auth.), H. Gerhard Vogel Prof., Franz Jakob Hock Dr., Jochen Maas Dr., Dieter Mayer Prof. (eds.)

ISBN-10: 3540256385

ISBN-13: 9783540256380

ISBN-10: 3540298045

ISBN-13: 9783540298045

ISBN-10: 3540334424

ISBN-13: 9783540334422

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Extra info for Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Example text

Passive Avoidance Test . . . . . . Morris Maze Test . . . . . . . . . Radial Maze Test . . . . . . . . . Social Recognition Test . . . . . . Delayed Alternation Test. . . . . . EEG Studies . . . . . . . . . . . QEEG . . . . . . . . . . . . . . Sleep/Wake Cycle . . . . . . . . . Drug Dependence and Abuse. . . . Drug Dependence . . . . . . . . . Non-Precipitated Withdrawal Test . Drug Abuse . . . . . .

Core Battery CNS Studies . . . . Irwin Test . . . . . . . . . . . . . Activity Meter Test . . . . . . . . Rotarod Test . . . . . . . . . . . Convulsive Threshold Tests . . . . Barbital Interaction Test . . . . . . Hot Plate Test . . . . . . . . . . . Supplementary CNS Studies . . . Cognitive Processes . . . . . . . . Passive Avoidance Test . . . . . . Morris Maze Test . . . . . . . . . Radial Maze Test . . . . .

Drug Dependence and Abuse. . . . Drug Dependence . . . . . . . . . Non-Precipitated Withdrawal Test . Drug Abuse . . . . . . . . . . . . Conditioned Place Preference Test . Drug Discrimination . . . . . . . . Self-Administration . . . . . . . . 1 General Considerations Definition of Safety Pharmacology Safety pharmacology studies are “those studies that investigate the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in the therapeutic dose-range and above” (Anon 2000).

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays by Franz J. Hock (auth.), H. Gerhard Vogel Prof., Franz Jakob Hock Dr., Jochen Maas Dr., Dieter Mayer Prof. (eds.)


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