By Jaime M. Monti, S. R. Pandi-Perumal, S. Chokroverty
This publication deals a entire yet hugely readable compilation of papers at the position of dopamine in sleep and sleep problems. prime specialists in sleep medication, psychiatry and neuroendocrinology offer a large standpoint at the box, from confirmed theories to the newest learn advances. consequently, it represents an interdisciplinary, state of the art advisor for sleep problem experts, sleep researchers, psychiatrists, neurologists, pulmonologists, psychologists, and behavioral sleep medication specialists.
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Extra resources for Dopamine and Sleep: Molecular, Functional, and Clinical Aspects
In an initial study in one patient who had been in a MCS for 5 months, amantadine had a dose-dependent effect on arousal as assessed by coma-near coma scores (Zafonte et al. 1998). More recently, in a placebo-controlled trial, amantadine accelerated the pace of functional recovery in patients with post-traumatic disorders of consciousness (Giacino et al. 2012). This is currently the only pharmacological agent which has been shown to be effective in improving clinical and motor function in VS/MCS in a well controlled clinical trial.
2011) whereas drugs that enhance the extracellular concentration of catecholamines by enhancing release or blocking reuptake increase wakefulness. Similarly, wakefulness is enhanced in dopamine transporter knock-out mice (Wisor et al. 2001). The localization of catecholamine neurons was facilitated by the development of the Falck-Hillarp staining technique which allowed visualization of their location based on the chemical reaction between catecholamines and formaldehyde, leading to cyclization of the catecholamines and the formation of strongly fluorescent products (Carlsson et al.
In Drosophila, dopamine promotes arousal by inhibition via D1-like receptors in the sleep-promoting dorsal fan-shaped body as well as D1-receptor effects on the mushroom body regions involved in learning and memory. E. Brown Genetic variations in dopamine clearance affect sleepiness associated with prolonged wakefulness. Alterations in the availability of dopamine D2 receptors in the nucleus accumbens following prolonged wakefulness may be involved in this homeostatic regulation of sleepiness. Dopaminergic stimulants effectively counteract this sleepiness and ameliorate cognitive impairments associated with sleep deprivation in mammals and in Drosophila, supporting the use of wake-promoting dopaminergic agents to treat excessive daytime sleepiness in narcolepsy and Parkinson’s disease.
Dopamine and Sleep: Molecular, Functional, and Clinical Aspects by Jaime M. Monti, S. R. Pandi-Perumal, S. Chokroverty