By Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri
This booklet examines the expression and serve as of ß1-integrins in articular chondrocytes. The authors talk about their learn and that of others fascinated with learning chondrocyte ECM adhesion and sign transduction.
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Extra resources for Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology)
36). This observation initially surprised us, but a more detailed study of the existing literature revealed that cellular responses and signalling cascades initiated by the influx of calcium or sodium through putative mechanosensitive channels in mechanically responsive cells may be regulated more effectively if such channels were organised around integrins with receptors, kinases and cytoskeletal complexes strategically clustered about them. Furthermore, the proximity of ATPase ion pumps such as Na, K-ATPase to chondrocyte mechanoreceptor complexes could possibly facilitate rapid homeostatic responses to the ionic perturbations brought about by activation of mechanically gated cation channels and efficiently regulate the intracellular milieu of chondrocytes (Shakibaei and Mobasheri 2003).
32A, B After dissolution of alginate by Ca2+-free medium, the chondrocytes (Ch) could be isolated and grown in organoid culture in vitro. During these processes, the cells did not lose contact with the extracellular matrix (not shown), and even maintained their matrix capsule. After cultivation of these cells in organoid culture for 7 days, a pure cartilage culture formed (A) showing the typical components of the cartilage matrix (M). The flat fibroblast-like cells (F) of the perichondrium are embedded in dense bundles of thick collagenous fibrils.
On day 7, α3 was present only in the newly formed cartilage nodules, whereas α1 was strongly expressed in the perichondrium and was further more or less homogeneously distributed in the surrounding mesenchyme. On day 14, α1-integrin was again detectable in the cartilage; this can be related to the observation Fig. 28A–E Immuno-labelling of β1-, α1- and α3-integrins as revealed by APAAP during chondrogenesis of limb bud mesenchymal cells from 12-day-old mouse embryos grown in organoid cultures. A, B After a culture period of 2 days, α1-integrin is uniformly detectable within the mesenchymal cell mass (*) and in the perichondrium (arrows), whereas α3-integrin can not be found.
Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology) by Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri