Press "Enter" to skip to content

New PDF release: Diverse Roles of Integrin Receptors in Articular Cartilage

By Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri

ISBN-10: 3540787704

ISBN-13: 9783540787709

ISBN-10: 3540787712

ISBN-13: 9783540787716

This booklet examines the expression and serve as of ß1-integrins in articular chondrocytes. The authors talk about their learn and that of others fascinated with learning chondrocyte ECM adhesion and sign transduction.

Show description

Read or Download Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology) PDF

Similar anatomy books

Musculoskeletal Ultrasound: Anatomy and Technique - download pdf or read online

Ultrasound is a powerful imaging modality more and more used for musculoskeletal assessment through radiologists, common practitioners, activities medication experts, and orthopedic surgeons alike. right ultrasound exam and interpretation hinges on thorough wisdom of correct anatomy, artifacts and approach.

Atlas of Functional Shoulder Anatomy by Andrea De Vita MD, W. Ben Kibler MD, FACSM (auth.), Giovanni PDF

The aim of this Atlas is to concentration the reader's consciousness on a chain of bone, ligament, muscle and tendon buildings and ultrastructures that experience no longer to date been mentioned other than within the newest foreign literature and in expert journals. This Atlas additionally offers tremendous high-definition photographs of "targeted" sections acquired from cadavers preserved utilizing state of the art ideas.

New PDF release: Biochemistry of Smooth Muscle Contraction

This important source offers a scientific account of the biochemistry of delicate muscle contraction. As a finished advisor to this speedily starting to be quarter of analysis, it covers the constitution and attribute homes of contractile and regulatory proteins, with specified emphasis on their estimated functionality within the dwell muscle.

New PDF release: Netter’s Concise Orthopaedic Anatomy

Netter’s Concise Orthopaedic Anatomy is a best-selling, transportable, full-color source very good to have available in the course of your orthopaedic rotation, residency, or as a brief look-up in perform. Jon C. Thompson provides the newest information in completely up-to-date diagnostic and remedy algorithms for all stipulations whereas protecting the preferred at-a-glance desk layout from the former version.

Extra resources for Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology)

Example text

36). This observation initially surprised us, but a more detailed study of the existing literature revealed that cellular responses and signalling cascades initiated by the influx of calcium or sodium through putative mechanosensitive channels in mechanically responsive cells may be regulated more effectively if such channels were organised around integrins with receptors, kinases and cytoskeletal complexes strategically clustered about them. Furthermore, the proximity of ATPase ion pumps such as Na, K-ATPase to chondrocyte mechanoreceptor complexes could possibly facilitate rapid homeostatic responses to the ionic perturbations brought about by activation of mechanically gated cation channels and efficiently regulate the intracellular milieu of chondrocytes (Shakibaei and Mobasheri 2003).

32A, B After dissolution of alginate by Ca2+-free medium, the chondrocytes (Ch) could be isolated and grown in organoid culture in vitro. During these processes, the cells did not lose contact with the extracellular matrix (not shown), and even maintained their matrix capsule. After cultivation of these cells in organoid culture for 7 days, a pure cartilage culture formed (A) showing the typical components of the cartilage matrix (M). The flat fibroblast-like cells (F) of the perichondrium are embedded in dense bundles of thick collagenous fibrils.

On day 7, α3 was present only in the newly formed cartilage nodules, whereas α1 was strongly expressed in the perichondrium and was further more or less homogeneously distributed in the surrounding mesenchyme. On day 14, α1-integrin was again detectable in the cartilage; this can be related to the observation Fig. 28A–E Immuno-labelling of β1-, α1- and α3-integrins as revealed by APAAP during chondrogenesis of limb bud mesenchymal cells from 12-day-old mouse embryos grown in organoid cultures. A, B After a culture period of 2 days, α1-integrin is uniformly detectable within the mesenchymal cell mass (*) and in the perichondrium (arrows), whereas α3-integrin can not be found.

Download PDF sample

Diverse Roles of Integrin Receptors in Articular Cartilage (Advances in Anatomy, Embryology and Cell Biology) by Mehdi Shakibaei, Constanze Csaki, Ali Mobasheri

by Mark

Rated 4.72 of 5 – based on 6 votes