By Erica A. Eugster, Ora Hirsch Pescovitz
Major researchers comprehensively translate the entire most recent clinical information about endocrine body structure and improvement into an knowing of the medical pathogenesis, prognosis, and therapy of endocrine affliction. equipped by way of endocrine method, every one element of the e-book concisely describes the chronological improvement of the human organism, from the fetal/prenatal interval via youth, youth, and often times, into maturity. The prenatal sections assessment fresh discoveries bearing on transcription elements, homeobox genes, and human molecular mutations-the uncomplicated methods governing prenatal improvement of the person endocrine organs-and element the pathophysiology, medical features, and therapy of pediatric endocrine issues.
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Extra resources for Developmental Endocrinology: From Research to Clinical Practice (Contemporary Endocrinology)
Mol Cell Endocrinol 2000;168:77–87. 22. Watanabe YG. Effects of brain and mesenchyme upon the cytogenesis of rat adenohypophysis in vitro. Cell Tissue Res 1982;227:257–266. 23. Watanabe YG. An organ culture study of the site of determination of ACTH and LH cells in the rat adenohypophysis. Cell Tissue Res 1982;227:267–275. 24. Daikoku S, Chikamori M, Adachi T, Maki Y. Effect of the basal diencephalon on the development of Rathke’s pouch in rats: a study in combined organ cultures. Dev Biol 1982;90:198–202.
A mutational hot spot in the PROP-1 gene in Russian children with combined pituitary hormone deficiency. Pituitary 1998; 1:45–49. 150. Fofanova O, Takamura N, Kinoshita E, Parks JS, Brown M, Peterkova V, et al.
During human embryo- Chapter 1 / Hypothalamic-Pituitary Axis 19 Fig. 5. Mutations of the PROP-1 anterior pituitary transcription factor identified as causing combined pituitary hormone deficiency in human patients and in rodent models. A schematic representation of the domains of the PROP-1 gene and protein are shown. Exons are labeled in Roman numerals. The functions of protein domains are indicated. Numbers denote the locations of mutations, and the nature of each mutation is described in the table below the protein diagram.
Developmental Endocrinology: From Research to Clinical Practice (Contemporary Endocrinology) by Erica A. Eugster, Ora Hirsch Pescovitz