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Connexins: The Gap Junction Proteins by Dr. Mahboob Ul Hussain PDF

By Dr. Mahboob Ul Hussain

ISBN-10: 813221918X

ISBN-13: 9788132219187

ISBN-10: 8132219198

ISBN-13: 9788132219194

Gap-junction proteins, connexins are very important mobile entities that control quite a few points of mobile body structure. The connexins represent huge family members of proteins. the current e-book offers simple assessment approximately a variety of features of connexin proteins. The e-book has attempted to the touch the elemental points of connexin relatives. This publication can be invaluable to large viewers that comes with under-and post-graduate scholars, learn students, clinicians, and so on. The reference part on the finish of the ebook could be beneficial in the event you search to grasp deeper information about this kin of proteins.

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Additional info for Connexins: The Gap Junction Proteins

Example text

However, proteins are the major cell entities that act as the actual business ends of the cell physiology. The transcriptional regulation of gene expression is just an initial step in the formation of proteins. Translation of mRNAs into proteins constitutes another important step in regulating the expression of proteins. For the proper functioning of a cell, the functional entities, which include the proteins, must be present at a defined concentration, at a particular time, and at a proper location.

3 Enzymes As mentioned previously, connexins are the target of various post-translational modifications, and among these, phosphorylation is the most prominent one. Most of the connexins are phosphoproteins and thus are the target of various kinases and phosphatases. The dynamics of phosphorylation and dephosphorylation regulates various aspects of connexin functions, like gating, interaction with other proteins, assembly and degradation, cell growth and differentiation, etc. For carrying out phosphorylation and dephosphorylation, it is imperative that 36 9 Interaction Partners of Connexin Proteins connexins interact with various kinases and phosphatases.

The transcription of connexin genes is controlled by of various transcription factors and other biological substances. The transcription factors play an important role in regulating the expression of connexin gene. The types of transcription factor(s) determine whether a particular connexin is expressed ubiquitously or in cell type-specific manner. In the following sections, the role of various transcription factors and other signalling molecules that regulate the ubiquitous or tissue-specific expression of connexin genes will be discussed.

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Connexins: The Gap Junction Proteins by Dr. Mahboob Ul Hussain


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