By Professor Dr. med. Alexis Labhart (auth.)
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Additional info for Clinical Endocrinology: Theory and Practice
Thyroid hormones are stored in an unusual manner, namely extracellularly in the colloid as components of thyroglobulin. Thyroxine and triiodothyronine are probably bound by peptide bonds to this large glycoprotein molecule. Release implies the expulsion of the hormone from its endocrine cell into the extracellular fluid. We have at present only limited information about the complex process by which hormones, which are often poorly fat-soluble, are transferred through the lipid-rich cell membrane.
In mathematical terms, therefore, these effector cells are sensitive to the first differential of hormone concentration against time. CLYNES (1961) showed that a "differential" sensitivity of this kind existed in the pupillary reaction to light stimuli. DALLMAN (1969) found evidence of an analogous phenomenon in an endocrine system, namely the action of corticosteroids on hypothalamic centers. G. Receptors For a hormone molecule to produce an effect it must come into direct physical contact with the target cell.
These syndromes have provided important information regarding the function of sex chromosomes. It may be of interest to the biochemically oriented geneticist to know that hormones were among the first proteins to have their amino acid sequences fully elucidated. Surprisingly, certain hormones with very different actions were found to be chemically closely related. Thus, large parts of the ACTH molecule are identical to the oc-MSH molecule and a whole subunit of the TSH molecule is identical with a subunit of the LH molecule.
Clinical Endocrinology: Theory and Practice by Professor Dr. med. Alexis Labhart (auth.)