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ISBN-10: 0470514280

ISBN-13: 9780470514283

ISBN-10: 0471934402

ISBN-13: 9780471934400

Utilizing a multidisciplinary process, it combines anatomical, mobile and physiological experiences through preeminent specialists. positive aspects vital insights into the functionality of the hypothalamus.

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Additional resources for Ciba Foundation Symposium 168 - Functional Anatomy of the Neuroendocrine Hypothalamus

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E. S. and W. V. are Clayton Foundation Investigators. References Alzein M, Jeandel L, Lutz-Bucher B, Koch B 1984 Evidence that CRF stimulates vasopressin secretion from isolated neurointermediate pituitary. Neuroendocrinol Lett 6:151 Antoni FA 1986 Hypothalamiccontrol of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev 7:351-378 Bicknell RJ 1985 Endogenous opioid peptides and hypothalamic neuroendocrine neurons. J Endocrinol 107:437-446 Brownstein MJ, Mezey E 1986 Multiple chemical messengers in hypothalamic magnocellular neurons.

J Neuroendocrinol 4:119-124 + Novartis Foundation Symposium Edited by Derek J. Chadwick, Joan M a s h Copyright 0 1992 by Ciba Foundation The relative importance of hypothalamic neurons containing corticotropinreleasing factor or vasopressin in the regulation of adrenocorticotropic hormone secretion G. B. Makara Institute of Experimental Medicine, HungarianAcademy of Sciences, PO Box 67, H- 1450 Budapest, Hungary Abstract. Corticotropin-releasing factor (CRF-41) and arginine vasopressin (AVP) are the two major factors that regulate adrenocorticotropic hormone (ACTH) secretion.

Warembourg & Poulain 1991), would suggest that gonadal steroids, specifically oestrogens, are principally involved. We (Sawchenko & Levin 1987) have found that treatment of ovariectomized rats with oestradiol enhances imrnunohistochemical staining for three peptides (dynorphin( 1-8), angiotensin I1 and galanin) in magnocellular vasopressinergic cells, while other peptides (dynorphin, cholecystokinin, CRF) co-localized with oxytocin were not affected. That these findings may hold some relevance to normal physiology is indicated by the fact that similar results were seen in normally cycling female rats killed at oestrus but not at other phases of the oestrous cycle.

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Ciba Foundation Symposium 168 - Functional Anatomy of the Neuroendocrine Hypothalamus


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