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By Marta Garaulet, Jose M. Ordovás

ISBN-10: 1461450810

ISBN-13: 9781461450818

Circadian rhythms are such an innate a part of our lives that we not often pause to invest why they even exist. a few experiences have instructed that the disruption of the circadian approach can be causal for weight problems and manifestations of Metabolic Syndrome (MetS). Shift-work, sleep-deprivation and bright-light-exposure at evening are concerning elevated adiposity (obesity) and incidence of MetS. it's been supplied facts of clock genes expression in human adipose tissue and tested its organization with diversified elements of the MetS. additionally, present reviews are illustrating the actual position of other clock genes variations and their envisioned haplotypes in MetS.

The objective of “Chronobiology and weight problems” is to explain the mechanisms implicated within the interplay among chonodisruption and metabolic-related health problems, resembling weight problems and MetS, with diverse approaches.

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Sleep Med Rev 6:113–124 53. Cajochen C, Münch M, Kobialka S, Kräuchi K, Steiner R, Oelhafen P, Orgül S, Wirz-Justice A (2005) High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light. J Clin Endocrinol Metab 90:1311–1316 54. Van Bommel WJ (2006) Non-visual biological effect of lighting and the practical meaning for lighting for work. Appl Ergon 37:461–466 55. Martinez-Nicolas A, Ortiz-Tudela E, Madrid JA, Rol MA (2011) Crosstalk between environmental light and internal time in humans.

Circadian Rhythmicity in Adipokines Other evidence that suggest a close relationship between circadian rhythms and adipose biology could be the fact that 24 h rhythms have been reported in the plasmatic concentration of leptin and adiponectin in humans [77, 78], being both adipokines. For example, leptin plasma levels during day are variables [77]. Normally, its peak is coinciding with the inactivity phase. Thus, in diurnal animals, such as humans, plasmatic leptin is high during night, when appetite decreases, and low during the day, when hunger increases [79].

2). SAT accumulates under the skin (known as peripheral fat mass) whereas VAT is located in the body cavity beneath the abdominal muscles and surrounding the intra-abdominal organs (well known as central fat mass). 36 P. Gómez-Abellán and M. Garaulet Visceral and Subcutaneous, Two Different Adipose Tissues Several studies have demonstrated that both depots, visceral and subcutaneous, are structural, physiological and metabolically different [51, 52]. Indeed, the type of fat cells or adipocytes, their endocrine function, lipolytic activity and the response to hormones differ between both adipose tissues.

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Chronobiology and Obesity by Marta Garaulet, Jose M. Ordovás


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