By Jerome B. Posner (auth.), Leonard Weiss Sc.D., M.D., Ph.D., Harvey A. Gilbert M.D., Jerome B. Posner M.D. (eds.)
Of these humans death with melanoma, many die due to metastases. then again, an incredibly small variety of texts were dedicated to this clinically very important subject. the current sequence of monographs originated in discussions, which confident us of the necessity for texts on metasasis which might include not just uncomplicated and scientific observations on humans and the place neces sary, on experimental animals but additionally discussions of the state-of-the-art in analysis and remedy. with a view to do so in-depth strategy, for which book used to be preceded via small workshops, it used to be essential to impose barriers at the scope of the subject. Metastasis is hence dis stubborn by means of website, and the sequence is equipped therefore. the 1st quantity within the sequence, Pulmonary Metastasis, used to be an improved model of a Workshop held at Roswell Park Memorial Institute in 1977. This, the second one quantity, is predicated on the same workshop on metastasis to the mind, held on the Memorial Sloan-Kettering melanoma heart in September, 1978. In organiz ing either the workshop and in modifying this quantity, we now have been excep tionally lucky to obtain the beneficiant cooperation of Dr. Jerome B. Posner, a practising neurologic oncologist who has given freely of his ex pertise during this really expert field.
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Extra resources for Brain Metastasis
Free of systemic disease 2. Not free of systemic disease a. Primary tumor unknown b. Systemic disease present but controlled c. Systemic disease uncontrolled WHY A MONOGRAPH ON BRAIN METASTASIS? Brain Metastases Are Common Frequency of Brain Metastasis The exact frequency of brain meta- stases in the cancer population is unknown. There are three general approaches to estimating their frequency: epidemiologic studies, clinical studies, and autopsy studies. Only a few epidemiologic studies have addressed the frequency of metastatic brain tumors.
J. Cancer 7:438-447, 1953. Onuigbo, W. I. B. Batson's theory of vertebral venous metastasis. Oncology 32:145-150, 1975. ; and Shimkin, M. B. Metastasis to pineal body. Arch. Pathol. 52:518-528,1951. 28 A CLINICIAN'S VIEW _ _ _ _ _ _ _ _ _ _ _ _ _ __ Paillas, J. , and Pellet, W. Brain metastases. In Handbook of Clinical Neurology, ed. P. J. Vinken and G. W. Bryn. , 1976. , and Tritapepe, R Considerazioni su 162 casi di metastasi endocraniche verificate. Minerva Chir. 12:269-285, 1957. Percy, A. K.
No Regeneration signs may not reverse _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ A CLINICIAN'S VIEW 25 A final unique characteristic of the brain is the fact that neurons do not reproduce. This fact has several implications. If neurons are damaged or destroyed, either by the metastasis itself or by treatment, function of that neuron is lost forever and regeneration cannot take place. On the obverse side, because neurons do not reproduce, they are considerably less sensitive to some of the agents used to treat tumors-agents whose effectiveness depends on destroying cells in the reproductive phase.
Brain Metastasis by Jerome B. Posner (auth.), Leonard Weiss Sc.D., M.D., Ph.D., Harvey A. Gilbert M.D., Jerome B. Posner M.D. (eds.)