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New PDF release: Biosimulation in Biomedical Research, Health Care and Drug

By Steen G. Dawids, Jakob L. Laugesen (auth.), Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan (eds.)

ISBN-10: 3709104173

ISBN-13: 9783709104170

ISBN-10: 3709104181

ISBN-13: 9783709104187

Biosimulation is an method of biomedical learn and the remedy of sufferers within which machine modeling is going hand in hand with experimental and scientific paintings. built types are used to interpret experimental effects and to acquire info from scan to experiment.

This e-book explains the techniques utilized in the modeling of organic phenomena and is going directly to current a chain of well-documented versions of the legislation of assorted genetic, mobile and physiological strategies. the best way how using laptop types permits optimization of melanoma remedy for person sufferers is mentioned and types of interacting nerve cells that may be used to layout new remedies for sufferers with Parkinson's affliction are defined. moreover this quantity presents an outline at the use of types in undefined, and offers the view of regulatory organisations at the topic.

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Additional info for Biosimulation in Biomedical Research, Health Care and Drug Development

Sample text

However, it is a system’s property and its occurrence depends on several other factors as well. We shall provide a more detailed discussion of the mechanisms involved in this type of instability in Chap. 4. 32 O. Lund et al. 7 HIV Vaccination and Anti-Retrovirus Therapy The purpose of a vaccination is to stimulate the immune system in such a way that it exhibits a fast and specific response to a given pathogen. Once the immediate stimulatory effect of the vaccination has died out, some of the B- and T-cells are converted into memory cells and, if a real infection later occurs, the memory cells will be turned back into B-cells and start to produce anti-bodies to neutralize the pathogen and assist the immune cells destroy it.

Dawids SG, Caspersen AH (1981) Compartmental and hemodynamic analysis of hemodialysis with a dynamic simulation model. ) 5:339–341 7. Forrester JW (1961) Industrial Dynamics. MIT Press, Massachusetts Institute of Technology 8. Jensen JI, Mosekilde E (1981) Dynamic analysis of the Hafnia A anaesthetic system. In: Paulr´e E (ed) System Dynamics and the Analysis of Change. North-Holland, Amsterdam 9. Mosekilde E, Jensen KS, Binder C, Pramming S, Thorsteinsson B (1989) Modelling absorption kinetics of subcutaneously injected soluble insulin.

Diagrams of this type are meant to help identifying the basic feedback structure of the system. In the form depicted in Fig. 1, the causal loop diagram only provides a very superficial picture of the insulin-glucose regulation. The diagram neglects, for instance, that brain and nerve cells can consume glucose without insulin, that insulin is degraded both in the liver and in muscle and adipose tissue, and that glucose may be released from the liver. The observant reader will also note that the glucose concentration in the blood does not control the insulin concentration.

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Biosimulation in Biomedical Research, Health Care and Drug Development by Steen G. Dawids, Jakob L. Laugesen (auth.), Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan (eds.)


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