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Extra resources for Bioactive Surfaces
10 (a) Structure of PS-b-PMEO3 MA. (b) Copolymer-modified surface in a hydrophobic environment and (c) in a hydrophilic environment. Reprinted, with permission, from . 3 Surface-Bounded Hydrogels A hydrogel is a crosslinked polymer network composed of water-swellable or water-soluble macromolecules. If the macromolecules are tethered to surfaces, the surface as such can act as a crosslinker. Therefore, almost any surface decorated with water-soluble or hydrophilic polymer chains may be regarded as a hydrogel .
Looking at the family of biofunctional analysis chips, one can state that DNA-chips are already well established on the market, with protein-chips starting to follow in their footprints. , living cells. , cells) to react to various environmental changes with a high specificity and sensitivity is as impressive as it is difficult to predict. Therefore, the search for substances that induce a certain (desired) cellular response either for medicinal purposes (drug-screening) or as coatings for medical implants (biocompatibility tests) is mainly done to date in extensive in vitro studies using cell culture assays.
2 Examples of Protein-Resistant Surface Coatings . . . . . . . . . . . . . . . . . . . S. Petersen, M. Gattermayer, and M. de 36 38 40 40 43 36 S. Petersen et al. 4 Directed Cell Adhesion to Engineered Surfaces . . . . . . . . . . . . . . . . . . . . . . . 1 Protein-Decorated Surfaces for Spatially Guided Cell Adhesion . . . . . . . . . . 2 Peptide-Decorated Surfaces for Spatially Guided Cell Adhesion. .
Bioactive Surfaces by Erik Wischerhoff, Nezha Badi, André Laschewsky, Jean-François Lutz (auth.), Hans G. Börner, Jean-Francois Lutz (eds.)