By Atta-Ur-Rahman Atta-Ur-Rahman
Usual items play an critical and ongoing function in selling quite a few features of clinical development, and lots of facets of easy examine courses are in detail regarding ordinary items. the importance, for this reason, of the reviews in average Product Chemistry sequence, edited by means of Professor Atta-ur-Rahman, can't be over priced. This quantity, in response to prior volumes, provides us with state-of-the-art contributions of serious significance.
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Extra resources for Bioactive Natural Products, Part C
1994, 270, 319-325. 38              [531  [551     [6o]          T. ROBINSON McCance, E. ; Price, L. ; Kosten, T. ; Jatlow, P. I. d. Pharmacol. Expt. , 1995, 274, 215-223. Landry, D. ; Yang, G. ; Georgiadis, T. M. Science, 1993, 259, 1899-1901. Dalvi, R. R; Jones, R. H. , 1986, 55, 558-561. Boelsterli, U. ; Oertle, M. Drug Metab. , 1992, 29, 96-101. ; Lang, M. ; Pasanen, M. Europ. J. , 1994, 270, 35-43.
In addition to its receptors, serotonin has transporter molecules; and there are alkaloids that interfere with the transport and uptake process. DNA's for serotonin transporters of rat leukemia cells have been cloned and sequenced. One of them has a 653 residue protein with 12-13 transmembrane domains. Interestingly they show considerable homology with transporters of some other transmitter substances; and are sensitive to cocaine, reserpine and several other alkaloids [229, 230, 231,232]. Thus the inhibitory action of serotonin can be reduced not only by substances that act on its receptor but also by substances that hinder its access to the receptor .
Cocaine indirectly raises the level of extracellular dopamine in the sustantia nigra by decreasing the number of kappa receptors [282. For binding to all receptors the free 3-hydroxyl group of morphine is important, so that codeine or morphine-3glucuronide have low affinity. The 3-glucuronide, lacking analgesic properties by itself, can nevertheless increase the analgesia produced by morphine. Thus it could be considered a regulator of morphine action . The 6-glucuronide has affinity equal to that of morphine for mu receptors but higher for delta receptors and lower for kappa receptors [271,284].
Bioactive Natural Products, Part C by Atta-Ur-Rahman Atta-Ur-Rahman