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Bioactive Natural Products: Opportunities and Challenges in - download pdf or read online

By Goutam Brahmachari

ISBN-10: 9814335371

ISBN-13: 9789814335379

Bioactive typical items are a wealthy resource of novel therapeutics. hence, the quest for bioactive molecules from nature maintains to play a major function in fashioning new medicinal brokers. This quantity, which contains 16 chapters written by way of energetic researchers and best specialists in ordinary items chemistry, brings jointly an summary of present discoveries during this notable box. It additionally offers info at the business program of usual items for medicinal reasons. This ebook will function a necessary source for researchers to foretell promising leads for constructing prescribed drugs to regard numerous diseases and ailment manifestations.

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This is caused by a lack of efficient dereplication methodologies for both natural product sourcing and compounds in the natural product libraries. The time-consuming processes of dereplication and purification are not compatible with the present regime of “blitz” screening campaigns in which assay support is only available for a limited duration (3 months). Besides, natural products are often structurally complex; modification of complex natural products using organic chemistry is frequently challenging.

History of medicine dates back practically to the existence of human civilization. Modern medicine system has gradually developed over the years by scientific and observational efforts of scientists; however, the basis of its development remains rooted in traditional medicine and therapies, prevailing throughout the world for thousands of years, which continue to provide mankind with new remedies. Plant-based medicines initially dispensed in the form of crude drugs such as tinctures, teas, poultices, powders, and other herbal formulations,6 now serve as the basis of novel drug discovery.

Qxd 9/7/2011 4:23 PM b1214 Page 17 Bioactive Natural Products Natural Products in Drug Discovery ADMET Target Identification Drug Discovery Stage Drug Development Stage (Product Formulation) 17 Clinical Trial Stage Approval Processes Launching of the drug on the market, after successful clinical trials followed by proper approvals Lead Optimization Rational Drug DesignBased Analog Synthesis Discovery of NP-Lead Bioactivity-Guided Screening, Isolation and Characterization of Natural Products (NPs) Fig.

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Bioactive Natural Products: Opportunities and Challenges in Medicinal Chemistry by Goutam Brahmachari

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