By Geyer H. J., Rimkus G. G., Scheunert I.
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Extra info for Bioaccumulation and Occurrence of Endocrine- Disrupting Chemicals (EDCs), Pers[...]umans(en)(166s)
B) A potential endocrine disrupter is a substance that possesses properties that might be expected to lead to endocrine disruption in an intact organism. Adverse hormonal effects may relate to disturbances in any of the major endocrine systems, including the reproductive, thyroid, and adrenal systems. (iv) Proendocrine-disrupting chemicals (PEDCs) are compounds that are not bound to steroid receptors. Example are methoxychlor and some non-planar polychlorinated biphenyls, which are actually proestrogens which after metabolization to mono- and diphenol metabolites can be bound to the estrogen receptor and produce estrogenic effects.
This drug can bind to the estrogen receptor, thereby blocking activation by endogenous estrogens. The breast cancer adjuvant non-steroidal pharmaceutical agent tamoxifen and its metabolite, 4-hydroxy tamoxifen, exhibit both antiestrogenic and estrogenic activities [149, 294]. Raloxifene is a nonsteroidal estrogen receptor mixed agonist/antagonist depending on the tissue. This drug is useful in preventing further bone loss when the onset of osteoporosis has been detected in woman after menopause.
C Data from Ahel and Giger . d Bioconcentration of 14C-NP determined by Ekelund et al. . e Bioconcentration in zebrafish determined by the kinetic method by Butte et al. . ) . g Determined by the HPLC method by Butte et al. . h Range of BCF values of PCP in mussels and different fish species compiled from the literature by Geyer et al. [173a]. W i Mean BCF value calculated by Geyer et al. [173a]. L j Tetrabromobisphenol-A showed no estrogenic effects in an eucaryotic test system (K.
Bioaccumulation and Occurrence of Endocrine- Disrupting Chemicals (EDCs), Pers[...]umans(en)(166s) by Geyer H. J., Rimkus G. G., Scheunert I.