By Francis S. Greenspan, David G. Gardner
The best-selling reference in endocrinology! Authoritative, concise, and present, this "all-in-one" textual content makes a speciality of the pathophysiology, prognosis, and therapy of endocrine issues. Written through well-known professionals and that includes greater than 350 two-color illustrations, the 7th variation has been up-to-date to mirror the newest in diagnostic checking out and molecular biology in addition to new techniques to scientific administration.
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Of Men without PCa Total 16,462 No. of men with positive PSA test resultb 175 (TP) 16,287 (FP) No. of men with negative PSA test resultc 25 (FN) 83,513 (TN) 83,538 200c 99,800 100,000 Total a Based on prostate biopsy ﬁndings. 0 ng/mL. 0 ng/mL. 7% Notice the marked effect of low disease prevalence on PPD+, with virtually no effect on PPD–, for a laboratory test with reasonably good sensitivity (89%) and speciﬁcity (84%). © 2009 by Taylor & Francis Group, LLC Endocrine and Metabolic Testing Manual, Fourth Edition xxx Area under the Curve (AUC) from a Receiver– Operator Characteristic (ROC) Curve Analysis Area under the curve (AUC) from a receiver–operator characteristic (ROC) curve analysis is a measure of the area under the curve of a plot of test values for 1 – speciﬁcity (x-axis) vs.
To avoid bias, individuals with disease are identiﬁed using tests and diagnostic procedures that do not include the test being evaluated and are selected without obvious bias; for example, using troponin I (TnI) levels to segregate individuals into no-disease or disease groups is not appropriate when evaluating the discriminatory power of TnI in discriminating between individuals with and without an acute coronary syndrome. , tests and diagnostic procedures accepted as the “gold standard” by the medical scientiﬁc community).
N Engl J Med 2001; 344:1743–9. Elmlinger MW, Kuhnel W, Lambrecht HG, Ranke MB. Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, free T4, thyroxine binding globulin (TBG), and thyrotropin (TSH). Clin Chem Lab Med 2001; 39:973–9. Ferretti E, Persani L, Jaffrain-Rea ML, Giambona S, Tamburrano G, Beck-Peccoz P. Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism. J Clin Endocrinol Metab 1999; 84:924–9.
Basic and Clinical Endocrinology by Francis S. Greenspan, David G. Gardner