By William T. Cefalu
The 1st atlas dedicated particularly to cardio-metabolic threat, this publication will offer a concise visible primer at the pathophysiology, epidemiology, prognosis, remedy, and scientific and radiologic good points of this illness. Describing contemporary care recommendations and present practices in sufferer evaluation, this resource will let clinicians to properly establish and deal with these sufferers at elevated probability for metabolic syndrome, heart problems, and diabetes.
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Extra info for Atlas of Cardiometabolic Risk
More recent evidence further implicates AMPK as having a pivotal role in energy balance. e. e. ‘energy expenditure’, in order to maintain a stable body weight. Major determinants of energy expenditure are: (1) the thermogenic effect of food (TEF), which represents the amount of energy utilized by ingestion and digestion of the food consumed; (2) physical activity; and (3) resting metabolic rate (RMR), determined in large measure by the amount of lean body mass. However, given the many obesity-promoting changes that have occurred in our environment, the whole-body energy balance has shifted toward being overweight and obese in many individuals at an alarming rate.
Insulin sensitivity differs among ethnic groups with a compensatory response in beta-cell function. Diabetes Care 2000; 23: 1353–8 5. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and β-cell 9. Reaven G. Syndrome X: 10 years after. Drugs 1999; 58 (Suppl 1):19–20 36 Cefalu Chapter 02 1/30/07 6:28 PM Page 37 INSULIN RESISTANCE AND CARDIOMETABOLIC RISK 10. Abate N. Insulin resistance and obesity: the role of fat distribution pattern. Diabetes Care 1996; 19: 292–4 11.
Insulin is stored in β-cells as hexamers complexed with zinc. Insulin–zinc hexamers readily form crystals which are stored in the pancreatic granules. In the blood, insulin is not seen in aggregated forms such as dimers or hexamers, but as monomers which are formed when insulin granules are liberated. 5 kg/m2). Caucasians; †data are geometric means. From reference 8 with permission to those seen in the general population, LDL compositional differences may make these particles more atherogenic. g.
Atlas of Cardiometabolic Risk by William T. Cefalu