By Ambikanandan Misra, Aliasgar Shahiwala
Use of polymers has turn into vital within the box of drug supply. Polymers play a vital function in modulating drug supply to use greatest healing merits and feature been primary within the profitable improvement of numerous novel drug supply platforms which are now available.
This booklet offers information of the purposes of polymeric drug supply platforms that might be of curiosity to researchers in industries and academia. It describes the advance of polymeric structures starting from the normal dosage varieties as much as the latest shrewdpermanent platforms. The regulatory and highbrow estate elements in addition to the medical applicability of polymeric drug supply structures also are discussed.
Each assorted drug supply course is mentioned in a separate bankruptcy of the booklet. All significant routes of drug supply were lined to supply the reader with a breathtaking in addition to an in-depth view of the advancements in polymer-based drug supply structures. Appendices are integrated which include beneficial pharmaceutical houses of the polymers and significant polymeric purposes for varied drug supply routes.
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Additional resources for Applications of polymers in drug delivery
In addition, altering the polymer and drug ratio in the formulation can facilitate the release of the drug from the polymeric drug delivery systems . Combination of polymers such as combining hydrophobic polymers with hydrophilic polymers to check the burst release effect due to quick hydration of hydrophilic polymer alone. The co-polymer ratio also affects the release kinetics. Drug targeting and controlled release can be achieved by specific ligand attachments to the polymers or by using already available polymers with modified architecture such as graft polymers, star-polymers, branched polymers and block polymers.
An example of this method is the delivery of chemotherapeutic agents to malignant gliomas using polyanhydrides . During treatment, polymer disks containing carmustine are implanted in cavities created after surgical removal of the tumour. 5 cm of the original tumour site. , the drug is unable to pass through the blood-brain barrier. For the majority of diseases that require distribution controlled release of drug, a targeting mechanism must be employed that allows the delivery system to find the desired target .
These crosslinks prevent the dissolution of the polymer and, thus, maintain the physical integrity of the dosage form. A balance between the extent and duration of swelling is maintained by the degree of crosslinking between the polymeric chains. A high degree of crosslinking retards the swelling ability of the system and maintains its physical integrity for a prolonged period. On the other hand, a low degree of crosslinking results in extensive swelling followed by the rapid dissolution of the polymer.
Applications of polymers in drug delivery by Ambikanandan Misra, Aliasgar Shahiwala