By Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons
This e-book studies the pathophysiology and actual manifestations of acromegaly and discusses the a number of treatments now on hand for the administration of the sufferer with acromegaly. The e-book comprises an plentiful variety of illustrations that aid to stress issues of specific curiosity, together with radiological, histopathological, and actual analysis photos. Sections are dedicated to detailing vital subject matters together with determinants of pathological results of sickness task in acromegaly, person healing offerings and standards for analysis, and disorder regulate.
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Extra info for Acromegaly: Pathology, Diagnosis and Treatment
37. Guillemin R. Peptides in the brain. The new endocrinology of the neuron. Nobel Lecture, December 1977. 1. A Historical Timeline 27 38. Salmon WD Jr, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 1957; 49:825–836. 39. Daughaday WH, Hall K, Raben MS, Salmon WD Jr, van den Brande JL, Van Wyk JJ. Somatomedin: proposed designation for sulphation factor. Nature 1972; 235:107. 40. Clemmons DR, Van Wyk JJ, Ridgway EC, Kliman B, Kjellberg RN, Underwood LE.
Source: K. Kovacs and A. Beckers 50 I. Pathology CAUSES OF ACROMEGALY More than 95% of cases of acromegaly occur sporadically due to a pituitary adenoma in patients without genetic disease traits that are associated with endocrine tumors. Approximately 1% of cases are caused by such familial or inherited endocrine diseases as multiple endocrine neoplasia type I (MEN-1). Pituitary carcinomas are very rare and only 140 of any type have been reported in the literature; GH-secreting pituitary carcinomas are usually hormonally active and can behave as invasive adenomas until they metastasize, or they may metastasize early (23).
Another regulator of GH secretion is ghrelin, a relatively recently identified hormone that is secreted primarily by the stomach which has a host of important regulatory effects on pituitary and gastrointestinal function and energy metabolism. Ghrelin was discovered some time after its receptor had been identified as a means for modulating GH secretion using GH secretagogues. The nature of the role of ghrelin in GH regulation is still being determined, however, it mediates a significant effect on somatotroph GH secretion.
Acromegaly: Pathology, Diagnosis and Treatment by Aart Jan van der Lely, Albert Beckers, Adrian Daly, Steven W. Lamberts, David R. Clemmons